Abstract
Two novel series of N-(2-guanidinoalkyl)-5-isoquinolinesulfonamides, 2 and 3, were prepared. Many of the compounds possessed vasodilatory activity when injected locally into the femoral artery of dogs. The most potent compound, 1-amidino-4-(5-isoquinolylsulfonyl)-1,4-perhydrodiazepine, 33, was comparable to diltiazem, which is used clinically as a vasodilator.
MeSH terms
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Animals
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Calcium Channel Blockers / chemical synthesis
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Dogs
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Female
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Femoral Artery / drug effects
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology
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Male
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis*
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Sulfonamides / pharmacology
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Vasodilator Agents / chemical synthesis*
Substances
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Calcium Channel Blockers
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Isoquinolines
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Sulfonamides
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Vasodilator Agents
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N-(2-guanidinoethyl)-5-isoquinolinesulfonamide