Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Melody Chemaly; Victoria McGilligan; Mark Gibson; Matthias Clauss; Steven Watterson; H Denis Alexander; Anthony John Bjourson; Aaron Peace

doi:10.1016/j.acvd.2017.08.002

Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Arch Cardiovasc Dis. 2017 Dec;110(12):700-711. doi: 10.1016/j.acvd.2017.08.002. Epub 2017 Oct 31.

Authors

Melody Chemaly¹, Victoria McGilligan², Mark Gibson³, Matthias Clauss⁴, Steven Watterson², H Denis Alexander², Anthony John Bjourson², Aaron Peace⁵

Affiliations

¹ Northern Ireland centre for stratified medicine, school of biomedical sciences, Ulster university, CTRIC building, Altnagelvin hospital, Glenshane Road, BT47 6SB Londonderry, Northern Ireland. Electronic address: el_chemaly-m@email.ulster.ac.uk.
² Northern Ireland centre for stratified medicine, school of biomedical sciences, Ulster university, CTRIC building, Altnagelvin hospital, Glenshane Road, BT47 6SB Londonderry, Northern Ireland.
³ Cardiology department, Western health and social care trust, Altnagelvin hospital, Glenshane road, BT47 6SB Londonderry, Northern Ireland.
⁴ Department of cellular and integrative physiology, Indiana university, Indianapolis, 46202 Indiana, USA; Centre for molecular bioscience, Ulster university, BT52 1SA Coleraine, Northern Ireland.
⁵ Northern Ireland centre for stratified medicine, school of biomedical sciences, Ulster university, CTRIC building, Altnagelvin hospital, Glenshane Road, BT47 6SB Londonderry, Northern Ireland; Cardiology department, Western health and social care trust, Altnagelvin hospital, Glenshane road, BT47 6SB Londonderry, Northern Ireland.

PMID: 29097110
DOI: 10.1016/j.acvd.2017.08.002

Abstract

Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFα) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.

Keywords: Atherosclerosis; Athérosclérose; Biomarker; Biomarqueur; Protéines transmembrannaires; TACE; TNFα; Transmembrane proteins.

Publication types

Review

MeSH terms

ADAM17 Protein / chemistry
ADAM17 Protein / metabolism*
Animals
Biomarkers / metabolism
Cardiovascular System / enzymology*
Cardiovascular System / physiopathology
Coronary Artery Disease / diagnosis
Coronary Artery Disease / enzymology*
Coronary Artery Disease / physiopathology
Enzyme Activation
Humans
Prognosis
Protein Conformation
Signal Transduction
Structure-Activity Relationship
Substrate Specificity

Substances

Biomarkers
ADAM17 Protein
ADAM17 protein, human