Longevity of implant-supported fixed partial dentures (ISFPDs) may be associated with multiple clinical complications, irrespective of whether retention is achieved via screws or cement. While use of screws ensures ease of prosthesis retrievability and elimination of the inherently risky cementation process, more mechanical strains are induced in this design. A combined screw-retrievable and cement-retained ISFPD is designed to achieve the best passive fit and strain reduction while allowing complete excess cement removal and maintaining ease of retrievability. Moreover, this approach suggests better protection of the cement layer from oral environment degradation and offers scope for an alternative retention protocol. This paper outlines aspects of the clinical indications and fabrication of a screw-retrievable, cement-retained ISFPD. A diagnostic assessment method that provides tactile resistance guidance for selection is also proposed.