Pericarditis associated with cytarabine therapy for acute myelocytic leukemia: a case report

Eur J Clin Pharmacol. 2018 Feb;74(2):181-182. doi: 10.1007/s00228-017-2355-7. Epub 2017 Oct 27.

Abstract

Background: The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide.

Description of the case: We are reporting a case of a 25-year-old male with acute myeloid leukemia (AML M2a) on chemotherapy who developed acute pericarditis after the administration of a cytarabine-containing regimen. The symptoms gradually improved after symptomatic treatment with steroids and other drugs.

Conclusions: This case demonstrates that, although pericarditis induced by cytarabine is rare, early recognition of this potentially life-threatening complication and appropriate management will usually result in the patient's recovery.

Keywords: Acute myeloid leukemia; Cytarabine; Pericarditis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimetabolites, Antineoplastic / adverse effects
  • Cytarabine / adverse effects*
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy
  • Male
  • Pericarditis / chemically induced*

Substances

  • Antimetabolites, Antineoplastic
  • Cytarabine