Existence of a novel qepA variant in quinolone resistant Escherichia coli from aquatic habitats of Bangladesh

Zillur Rahman; Aminul Islam; Mahamud-Ur Rashid; Fatema-Tuz Johura; Shirajum Monira; Haruo Watanabe; Niyaz Ahmed; Andrew Camilli; Munirul Alam

doi:10.1186/s13099-017-0207-8

Existence of a novel qepA variant in quinolone resistant Escherichia coli from aquatic habitats of Bangladesh

Gut Pathog. 2017 Oct 23:9:58. doi: 10.1186/s13099-017-0207-8. eCollection 2017.

Authors

Affiliations

¹ International Center for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, 1212 Bangladesh.
² Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan.
³ Department of Molecular Biology and Microbiology, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, USA.

^# Contributed equally.

Abstract

Of 19 environmental Escherichia coli (n = 12) and Klebsiella pneumoniae (n = 7) tested for quinolone resistance-related genes qnrA, qnrB, qnrC, qnrS and qepA, four each of E. coli and K. pneumoniae possessed qnrS, and another E. coli isolate possessed a new variant of qepA. This is the first detection of qepA in environmentally dwelling bacteria in Bangladesh.

Keywords: Bangladesh; Escherichia coli; Novel qepA variant; Quinolone resistance; qepA4.