Defining Native Enhancer Function

Miles A Pufall

doi:10.1016/j.cels.2017.10.008

Defining Native Enhancer Function

Cell Syst. 2017 Oct 25;5(4):310-312. doi: 10.1016/j.cels.2017.10.008.

Author

Miles A Pufall¹

Affiliation

¹ Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: miles-pufall@uiowa.edu.

PMID: 29073368
DOI: 10.1016/j.cels.2017.10.008

Abstract

CRISPR inhibition is used to ablate the activity of regulatory elements alone and in combination, functionally linking regulatory elements to genes and revealing the logic of how these elements collaborate in their native genomic context.

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MeSH terms

Clustered Regularly Interspaced Short Palindromic Repeats
Enhancer Elements, Genetic*
Estrogen Receptor alpha*
Gene Expression Regulation
Genomics

Substances

Estrogen Receptor alpha