Abstract
A new eremophilane sesquiterpene, 13,13-dimethoxyintegric acid (1), together with known compound integric acid (2) have been isolated from a fungus, Xylaria sp. V-27, obtained from a dead branch. The structure of 1 was established by means of spectroscopic analyses. 1 and 2 promoted growth restoring activity against the mutant yeast strain (Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)) and inhibited degranulation of rat basophilic leukemia RBL-2H3 cells stimulated by immnunoglobulin G + 2,4-dinitrophenylated-bovine serum albumin (IgE+DNP-BSA), thapsigargin and A23187.
MeSH terms
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Animals
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Carboxylic Acids / isolation & purification
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Carboxylic Acids / pharmacology*
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Cell Degranulation / drug effects*
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Cell Line, Tumor
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Naphthalenes / isolation & purification
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Naphthalenes / pharmacology*
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Polycyclic Sesquiterpenes
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Rats
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / growth & development*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Xylariales / metabolism
Substances
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13,13-dimethoxyintegric acid
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Carboxylic Acids
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Naphthalenes
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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eremophilane compounds
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integric acid