A hitchhiker's guide to lesion-behaviour mapping

Bianca de Haan; Hans-Otto Karnath

doi:10.1016/j.neuropsychologia.2017.10.021

A hitchhiker's guide to lesion-behaviour mapping

Neuropsychologia. 2018 Jul 1:115:5-16. doi: 10.1016/j.neuropsychologia.2017.10.021. Epub 2017 Oct 21.

Authors

Bianca de Haan¹, Hans-Otto Karnath²

Affiliations

¹ Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address: bianca.dehaan@brunel.ac.uk.
² Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Department of Psychology, University of South Carolina, Columbia, USA.

PMID: 29066325
DOI: 10.1016/j.neuropsychologia.2017.10.021

Abstract

Lesion-behaviour mapping is an influential and popular approach to anatomically localise cognitive brain functions in the human brain. Multiple considerations, ranging from patient selection, assessment of lesion location and patient behaviour, spatial normalisation, statistical testing, to the anatomical interpretation of obtained results, are necessary to optimize a lesion-behaviour mapping study and arrive at meaningful conclusions. Here, we provide a hitchhiker's guide, giving practical guidelines and references for each step of the typical lesion-behaviour mapping study pipeline.

Keywords: Brain behaviour inference; Human; Lesion analysis; VLBM; VLSM; Voxel based lesion symptom mapping.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / diagnostic imaging
Brain / pathology*
Brain Injuries / diagnostic imaging
Brain Injuries / pathology*
Brain Mapping / methods*
Brain Mapping / standards*
Humans