Hydrogen-peroxide and silicone-hydrogel contact lenses: Worsening of external eye condition and tear film instability

Abstract

Purpose: The aim is discussing the origins of worsening of external eye condition (EEC) and of tear film (TF) instability after wear of silicone-hydrogel contact lenses (CLs) with hydrogen-peroxide (H₂O₂) care system.

Methods: EEC and TF stability were evaluated before and after 15days of wear combined with different care systems: (1) H₂O₂, (2) detergent solution and H₂O₂, (3) multipurpose solution (MPS), (4) H₂O₂ and artificial tears. In-vitro cell mortality tests were performed after 24h cell incubation with CLs treated with H₂O₂. Photon correlation spectroscopy (PCS) was carried out on tears of non-wearers and CL wearers who used MPS or H₂O₂ solution.

Results: Worsening of EEC was observed only for the group using H₂O₂ (group 1). In-vitro, cell mortality was found higher for worn CL than for unworn CLs. Worsening of TF stability was observed regardless of care system and also PCS results on tears of CL wearers were found different compared to non-wearers regardless of care system. The only observed remedy for tear instability of CL wearers was found to be the administration of artificial tears.

Conclusions: Worsening of EEC of CL wearers using H₂O₂ is attributed to H₂O₂ scarce cleaning efficacy, which can be solved by adding a CL detergent solution. The origin of TF instability is found to be different. A remedy was found to be the administration of artificial tears, whose effect could be attributed either to the role of specific components or to rinsing and replacement of TF during wear.

Keywords: Care solutions; Contact lenses; External eye; Hydrogen peroxide; Tear film.