Integrative cancer pharmacogenomics to establish drug mechanism of action: drug repurposing

Pharmacogenomics. 2017 Nov;18(16):1469-1472. doi: 10.2217/pgs-2017-0132. Epub 2017 Oct 23.

Authors

Nehme El-Hachem¹, Wail Ba-Alawi^{1

2}, Ian Smith^{1

2}, Arvind Singh Mer^{1

2}, Benjamin Haibe-Kains^{1

2

3

4}

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
² Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
³ Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
⁴ Ontario Institute of Cancer Research, Toronto, Ontario, Canada.

PMID: 29057710
DOI: 10.2217/pgs-2017-0132

No abstract available

Keywords: cancer; drug repurposing; integrative analysis; machine learning; pharmacogenomics.

MeSH terms

Computational Biology / methods
Drug Discovery / methods*
Drug Repositioning / methods*
Humans
Neoplasms / drug therapy*
Pharmacogenetics / methods*