A Case of a Newborn With Blocked RhD Antigen and HDFN

Haijuan Wang; Jian Chen; Yongmei Jiang

doi:10.1093/labmed/lmx061

A Case of a Newborn With Blocked RhD Antigen and HDFN

Lab Med. 2017 Nov 8;48(4):381-383. doi: 10.1093/labmed/lmx061.

Authors

Haijuan Wang¹, Jian Chen¹, Yongmei Jiang¹

Affiliation

¹ Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

PMID: 29053863
DOI: 10.1093/labmed/lmx061

Abstract

A group O RhD-negative pregnant patient with anti-D antibody at titer 1:2048 delivered a baby boy by cesarean section at 38 + 6 weeks gestational age. The neonate typed as group O, but D antigen was at first uncertain. DAT and antibody screen of newborn were both positive. Various assays were used for D antigen determination. Ultimately, D antigen blocked by high-titer maternal anti-D antibody was confirmed. Total bilirubin of the newborn was 52.7 umol/L, and hemoglobin was 1.46 mg/dL. O RhD-negative red cells were used for an exchange transfusion.

Keywords: HDFN; blocked RhD antigen; blood group typing.

Publication types

Case Reports

MeSH terms

Blood Grouping and Crossmatching
Erythroblastosis, Fetal / diagnosis*
Humans
Infant, Newborn
Male
Rho(D) Immune Globulin / blood*

Substances

Rho(D) Immune Globulin