5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer

Nat Prod Res. 2018 Dec;32(24):2964-2967. doi: 10.1080/14786419.2017.1392954. Epub 2017 Oct 20.

Abstract

Vascular endothelial growth factor (VEGF) is a glycoprotein vital to the regulation of vascular endothelial cells proliferation, migration and angiogenesis. The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis. The present study investigated the effect of 5,6-dehydrokawain isolated from the rhizomes of Alpinia mutica on VEGF expression in vitro using HT-29 cell line. The results revealed that 5,6-dehydrokawain induced the expression of proangiogenic tumour-derived VEGF of HT-29 cells, which may explain the inability of 5,6-dehydrokawain in suppressing cancer cells proliferation.

Keywords: 5,6-dehydrokawain; VEGF; angiogenesis, HT-29 cells.

MeSH terms

  • Alpinia / anatomy & histology
  • Alpinia / chemistry*
  • Angiogenesis Modulating Agents / isolation & purification
  • Angiogenesis Modulating Agents / pharmacology
  • Cell Proliferation / drug effects
  • Colorectal Neoplasms / metabolism*
  • Colorectal Neoplasms / pathology
  • HT29 Cells
  • Humans
  • Neovascularization, Pathologic / chemically induced
  • Plant Extracts / pharmacology
  • Pyrones / isolation & purification
  • Pyrones / pharmacology*
  • Rhizome / chemistry*
  • Vascular Endothelial Growth Factor A / drug effects*
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Angiogenesis Modulating Agents
  • Plant Extracts
  • Pyrones
  • Vascular Endothelial Growth Factor A
  • 5,6-dehydrokawain