Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology

Adv Exp Med Biol. 2017:1018:91-127. doi: 10.1007/978-981-10-5765-6_7.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman's disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.

Keywords: KSHV epidemiology; KSHV life cycle; KSHV pathogenesis; Kaposi’s sarcoma-associated herpesvirus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Acquired Immunodeficiency Syndrome / genetics*
  • Acquired Immunodeficiency Syndrome / virology
  • Castleman Disease / epidemiology
  • Castleman Disease / genetics*
  • Castleman Disease / virology
  • Herpesvirus 8, Human / genetics*
  • Herpesvirus 8, Human / pathogenicity
  • Humans
  • Oncogenic Viruses / genetics
  • Oncogenic Viruses / pathogenicity
  • Sarcoma, Kaposi / epidemiology
  • Sarcoma, Kaposi / genetics*
  • Sarcoma, Kaposi / virology

Supplementary concepts

  • Multi-centric Castleman's Disease