Magnetic nanohydrogel obtained by miniemulsion polymerization of poly(acrylic acid) grafted onto derivatized dextran

Rodolfo Debone Piazza; Eloiza da Silva Nunes; Wesley Renato Viali; Sebastião William da Silva; Fermin Herrera Aragón; José Antônio Huamaní Coaquira; Paulo César de Morais; Rodrigo Fernando Costa Marques; Miguel Jafelicci Júnior

doi:10.1016/j.carbpol.2017.09.019

Magnetic nanohydrogel obtained by miniemulsion polymerization of poly(acrylic acid) grafted onto derivatized dextran

Carbohydr Polym. 2017 Dec 15:178:378-385. doi: 10.1016/j.carbpol.2017.09.019. Epub 2017 Sep 7.

Authors

Rodolfo Debone Piazza¹, Eloiza da Silva Nunes², Wesley Renato Viali², Sebastião William da Silva³, Fermin Herrera Aragón³, José Antônio Huamaní Coaquira³, Paulo César de Morais⁴, Rodrigo Fernando Costa Marques⁵, Miguel Jafelicci Júnior⁵

Affiliations

¹ Laboratory of Magnetic Materials and Colloids, Departament of Physical Chemistry, Institute of Chemistry, São Paulo State University, Araraquara, SP, 14801-970, Brazil. Electronic address: rodolfo.piazza@iq.unesp.br.
² Instituto Federal Goiano, Rio Verde, GO 75901-970, Brazil.
³ Instituto de Física, Núcleo de Física Aplicada, Universidade de Brasília, Brasília, DF, 70910-900, Brazil.
⁴ Anhui University, School of Chemistry and Chemical Engineering, Hefei 230601, China.
⁵ Laboratory of Magnetic Materials and Colloids, Departament of Physical Chemistry, Institute of Chemistry, São Paulo State University, Araraquara, SP, 14801-970, Brazil.

PMID: 29050608
DOI: 10.1016/j.carbpol.2017.09.019

Abstract

This study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy (¹³C NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5.27nm. The entrapment of iron oxide nanoparticles in a dextran nanohydrogel matrix was confirmed by thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and Zeta potential data. The magnetic nanohydrogels presented superparamagnetic behavior and were colloidal stable in physiological during 30days. Our findings suggest that the synthesized magnetic nanohydrogel are potential candidates for use in drug delivery systems due to its physicochemical and magnetic properties.

Keywords: Derivatized dextran; Iron oxide; Miniemulsion polymerization; Nanohydrogels.