Report of a Novel Case of Anaplastic Olfactory Groove Meningioma and Its Methylation Subtype

Abstract

We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolent SMO subtype lesions, our report suggests that even though rare, aggressive NF2 subtype meningiomas can also occur along the midline anterior skull base.

Keywords: Anaplastic meningioma; NF2; Olfactory groove.