Peptides for optical medical imaging and steps towards therapy

Matteo Staderini; Alicia Megia-Fernandez; Kevin Dhaliwal; Mark Bradley

doi:10.1016/j.bmc.2017.09.039

Peptides for optical medical imaging and steps towards therapy

Bioorg Med Chem. 2018 Jun 1;26(10):2816-2826. doi: 10.1016/j.bmc.2017.09.039. Epub 2017 Sep 30.

Authors

Matteo Staderini¹, Alicia Megia-Fernandez¹, Kevin Dhaliwal², Mark Bradley³

Affiliations

¹ School of Chemistry, EaStChem, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, UK.
² EPSRC IRC Proteus Hub, MRC Centre of Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
³ School of Chemistry, EaStChem, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, UK; EPSRC IRC Proteus Hub, MRC Centre of Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address: mark.bradley@ed.ac.uk.

PMID: 29042225
DOI: 10.1016/j.bmc.2017.09.039

Abstract

Optical medical imaging is a rapidly growing area of research and development that offers a multitude of healthcare solutions both diagnostically and therapeutically. In this review, some of the most recently described peptide-based optical probes are reviewed with a special emphasis on their in vivo use and potential application in a clinical setting.

Keywords: Disease imaging; Fluorescence; Guided surgery; Peptides.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Affinity Labels / chemistry
Animals
Fluorescent Dyes / chemistry*
Humans
Microscopy, Fluorescence / methods
Optical Imaging / methods*
Peptides / chemistry*

Substances

Affinity Labels
Fluorescent Dyes
Peptides