Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

Biomater Sci. 2017 Nov 21;5(12):2393-2397. doi: 10.1039/c7bm00826k.

Abstract

Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine-glycine-aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.

MeSH terms

  • Cell Line, Tumor
  • Contrast Media / chemistry
  • Contrast Media / therapeutic use
  • Dendrimers / chemistry
  • Dendrimers / therapeutic use*
  • Gene Expression Regulation, Neoplastic
  • Gold / chemistry
  • Humans
  • Integrin alpha5 / genetics
  • Integrin beta3 / genetics
  • Metal Nanoparticles / chemistry
  • Metal Nanoparticles / therapeutic use*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / drug therapy
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Pathology, Molecular
  • Peptides / chemistry
  • Peptides / therapeutic use*
  • Single Photon Emission Computed Tomography Computed Tomography
  • Technetium / therapeutic use

Substances

  • Contrast Media
  • Dendrimers
  • Integrin alpha5
  • Integrin beta3
  • Peptides
  • Technetium
  • Gold