A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin related receptor on Alzheimer’s disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations. Given thesedata, crucial evidence is provided to demonstrate that a significantrelationship exists between SORL1 polymorphisms and susceptibility to Alzheimer’s disease.
Keywords: Alzheimer’s disease; neurogenomics; single nucleotide polymorphisms; sortilin-related receptor.