Pregnancy in immunoglobulin M nephropathy

J Obstet Gynaecol Res. 2018 Jan;44(1):157-160. doi: 10.1111/jog.13489. Epub 2017 Oct 13.

Abstract

Immunoglobulin M nephropathy is an uncommon glomerular disease and a relatively less recognized clinico-immunopathological entity in the domain of glomerulonephritis, often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis. It is characterized by asymptomatic hematuria, episodes of macroscopic hematuria and proteinuria. Corticosteroids remain the mainstay of therapeutic strategies for such patients. We present what we believe to be the first known case of successful pregnancy in a 40-year-old woman with a 12-year history of underlying immunoglobulin M nephropathy. In view of the rarity of this disease we hope this report will assist professionals managing such cases.

Keywords: immunoglobulin M; pre-eclampsia/eclampsia; renal and hypertension.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Autoimmune Diseases* / drug therapy
  • Autoimmune Diseases* / immunology
  • Autoimmune Diseases* / urine
  • Female
  • Glomerulonephritis* / drug therapy
  • Glomerulonephritis* / immunology
  • Glomerulonephritis* / urine
  • Humans
  • Immunoglobulin M / immunology*
  • Live Birth
  • Pregnancy
  • Pregnancy Complications* / drug therapy
  • Pregnancy Complications* / immunology
  • Pregnancy Complications* / urine

Substances

  • Adrenal Cortex Hormones
  • Immunoglobulin M