Practical considerations when analyzing discrete survival times using the grouped relative risk model

Lifetime Data Anal. 2018 Jul;24(3):532-547. doi: 10.1007/s10985-017-9410-7. Epub 2017 Oct 11.

Abstract

The grouped relative risk model (GRRM) is a popular semi-parametric model for analyzing discrete survival time data. The maximum likelihood estimators (MLEs) of the regression coefficients in this model are often asymptotically efficient relative to those based on a more restrictive, parametric model. However, in settings with a small number of sampling units, the usual properties of the MLEs are not assured. In this paper, we discuss computational issues that can arise when fitting a GRRM to small samples, and describe conditions under which the MLEs can be ill-behaved. We find that, overall, estimators based on a penalized score function behave substantially better than the MLEs in this setting and, in particular, can be far more efficient. We also provide methods of assessing the fit of a GRRM to small samples.

Keywords: Bias reduction; Discrete survival times; Efficiency; Grouped relative risk model; Penalized score function; Small samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bias
  • Humans
  • Likelihood Functions
  • Regression Analysis
  • Risk Assessment / statistics & numerical data
  • Survival Analysis*
  • Survival Rate