Abstract
Two new gallic acid glycosides, potentillanosides G (1) and H (2), were newly isolated from the methanol extract of the tuberous roots of Potentilla anserina (Rosaceae), together with a known compound, ellagic acid 3-O-α-L-rhamnopyranoside (3). Their structures were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, potentillanoside H (2, IC50 = 99.5 μM) was found to show hepatoprotective activity.
Keywords:
Ellagic acid glycoside; Hepatoprotective activity; Potentilla anserina; Potentillanoside; Rosaceae.
MeSH terms
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Acetates / chemistry
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Animals
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Cell Survival / drug effects
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Cells, Cultured
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Cytoprotection
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Ellagic Acid / isolation & purification*
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Ellagic Acid / pharmacology
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Hepatocytes / drug effects*
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Hepatocytes / physiology
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Inhibitory Concentration 50
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Medicine, Tibetan Traditional
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Methanol / chemistry
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Mice
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Molecular Structure
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Plant Roots / chemistry
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Potentilla / chemistry*
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Solvents / chemistry
Substances
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Acetates
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Glycosides
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Plant Extracts
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Solvents
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Ellagic Acid
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ethyl acetate
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Methanol