Abstract
5-[(p-Carborane-2-yl)ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases.
Keywords:
Carboranes; DNA polymerase; Nucleoside triphosphates; Nucleotides; Oligonucleotides.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boranes / chemistry*
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DNA / biosynthesis*
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DNA / chemistry
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DNA Primers / chemistry
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DNA Primers / metabolism*
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DNA-Directed DNA Polymerase / metabolism*
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Deoxyuracil Nucleotides / chemistry*
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Oligonucleotides / biosynthesis
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Oligonucleotides / chemistry
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Polymerase Chain Reaction
Substances
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Boranes
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DNA Primers
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Deoxyuracil Nucleotides
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Oligonucleotides
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deoxyuridine triphosphate
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DNA
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DNA-Directed DNA Polymerase