Opioid Resistance Associated with CYP3A4 Hyperactivity and COMT Polymorphism in an Oncological Patient

Pain Med. 2018 Mar 1;19(3):638-640. doi: 10.1093/pm/pnx186.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Analgesics, Opioid / pharmacokinetics*
  • Analgesics, Opioid / therapeutic use*
  • Cancer Pain / drug therapy
  • Catechol O-Methyltransferase / genetics*
  • Cytochrome P-450 CYP3A / metabolism*
  • Drug Resistance / physiology*
  • Endometrial Neoplasms / complications
  • Female
  • Genotype
  • Humans
  • Polymorphism, Single Nucleotide

Substances

  • Analgesics, Opioid
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • COMT protein, human
  • Catechol O-Methyltransferase