Abstract
Of 250 clinical isolates of Escherichia coli obtained in Nepal, 38 were carbapenem resistant, with MICs of imipenem or meropenem of ≥4 μg/ml. All 38 isolates harbored the following blaNDMs: blaNDM-1, blaNDM-3, blaNDM-4, blaNDM-5, blaNDM-7, blaNDM-12, and blaNDM-13 Most of these isolates also harbored the 16S rRNA methylase gene(s) armA, rmtB, and/or rmtC.
Keywords:
NDM-type metallo-β-lactamase; carbapenem-resistant Escherichia coli; molecular epidemiology.
Copyright © 2017 American Society for Microbiology.
MeSH terms
-
Anti-Bacterial Agents / pharmacology*
-
Escherichia coli / drug effects
-
Escherichia coli / enzymology
-
Escherichia coli / genetics*
-
Escherichia coli / isolation & purification
-
Escherichia coli Infections / drug therapy
-
Escherichia coli Infections / epidemiology*
-
Escherichia coli Infections / microbiology
-
Escherichia coli Proteins / genetics
-
Escherichia coli Proteins / metabolism
-
Gene Expression
-
Humans
-
Imipenem / pharmacology
-
Isoenzymes / genetics
-
Isoenzymes / metabolism
-
Meropenem
-
Methyltransferases / genetics
-
Methyltransferases / metabolism
-
Microbial Sensitivity Tests
-
Molecular Epidemiology
-
Multilocus Sequence Typing
-
Mutation*
-
Nepal / epidemiology
-
Plasmids / chemistry
-
Plasmids / metabolism
-
Sequence Analysis, DNA
-
Thienamycins / pharmacology
-
beta-Lactam Resistance / genetics*
-
beta-Lactamases / genetics*
-
beta-Lactamases / metabolism
Substances
-
Anti-Bacterial Agents
-
Escherichia coli Proteins
-
Isoenzymes
-
Thienamycins
-
Imipenem
-
ArmA protein, E coli
-
Methyltransferases
-
RmtB protein, E coli
-
beta-Lactamases
-
beta-lactamase NDM-1
-
Meropenem