Cognitive Changes Related to Cancer Therapy

Med Clin North Am. 2017 Nov;101(6):1115-1134. doi: 10.1016/j.mcna.2017.06.006. Epub 2017 Aug 25.

Abstract

A growing population of cancer survivors is at risk for acute and long-term consequences resulting from cancer and its treatment. Cancer-related cognitive impairment (CRCI) typically manifests as modest deficits in attention, processing speed, executive functioning, and memory, which may persist for decades after treatment. Although some risk factors for CRCI are largely immutable (eg, genetics and demographic factors), there are many other contributors to CRCI that when appropriately addressed can result in improved cognitive functioning and quality of life. Neuropsychological assessment can help identify patient cognitive strengths and weaknesses, target psychological and behavioral contributors to CRCI, and guide treatment interventions.

Keywords: Cancer; Cancer-related cognitive impairment; Chemo brain; Chemo fog; Cognition; Neuropsychological functioning.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Antineoplastic Agents / adverse effects*
  • Attention
  • Cognitive Dysfunction / etiology*
  • Executive Function
  • Genetic Predisposition to Disease
  • Humans
  • Learning
  • Life Style
  • Neoplasms / complications*
  • Neoplasms / physiopathology
  • Neoplasms / psychology*
  • Neoplasms / therapy
  • Quality of Life
  • Radiotherapy / adverse effects*
  • Risk Factors
  • Socioeconomic Factors

Substances

  • Antineoplastic Agents