Inflammaging and the Lung

Elizabeth J Kovacs; Devin M Boe; Lisbeth A Boule; Brenda J Curtis

doi:10.1016/j.cger.2017.06.002

Inflammaging and the Lung

Clin Geriatr Med. 2017 Nov;33(4):459-471. doi: 10.1016/j.cger.2017.06.002. Epub 2017 Jul 14.

Authors

Elizabeth J Kovacs¹, Devin M Boe², Lisbeth A Boule³, Brenda J Curtis⁴

Affiliations

¹ Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, GILIIP (GI, Liver and Innate Immunity Program), Graduate Program in Immunology, IMAGE (Investigations in Metabolism, Aging, Gender and Exercise), University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Mailstop #8620, Aurora, CO 80045, USA. Electronic address: elizabeth.kovacs@ucdenver.edu.
² Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, Graduate Program in Immunology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Room 6460, Aurora, CO 80045, USA.
³ Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, IMAGE, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Room 6460, Aurora, CO 80045, USA.
⁴ Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, IMAGE, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Room 6018, Aurora, CO 80045, USA.

Abstract

With the coming of the "silver tsunami," expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is timely and of immediate clinical need. The global population is increasing in age. By the year 2030, more than 20% of the population of the United States will be older than 65 years of age. This article focuses on how advanced age alters the immune systems and how this, in turn, modulates the ability of the aging lung to deal with infectious challenges from the outside world and from within the host.

Keywords: Elderly; Host defense; Immunosenescence; Infection; Inflammaging; Inflammation; Macrophage; Neutrophils.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Aged
Aging / immunology*
Humans
Immune System* / pathology
Immune System* / physiopathology
Immunosenescence*

Abstract

Publication types

MeSH terms

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