Abstract
The synthesis and characterization of new N-donor bitriazolic tripods were reported. The in vitro antibacterial and antifungal activities of these products were screened against fungal strain (Candida pelliculosa) and against four bacterial strains (Micrococcus luteus, Bacillus subtilis, Listeria innocua, and Escherichia coli). Biological data revealed the effect of the chemical structure on antimicrobial activity. Molecular docking studies of some compounds showed that they could act as inhibitors for the biotin carboxylase enzyme.
Keywords:
Antibacterial activity; Antifungal activity; Structure-activity relationships; Triazole; Tripodal ligand.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Bacillus subtilis / drug effects
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Binding Sites
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Candida / drug effects
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Carbon-Nitrogen Ligases / chemistry
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Carbon-Nitrogen Ligases / metabolism
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Catalytic Domain
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / metabolism
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Ligands
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Listeria / drug effects
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Docking Simulation
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Structure-Activity Relationship
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Thermodynamics
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Triazoles / chemical synthesis
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Triazoles / chemistry*
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Triazoles / pharmacology
Substances
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Anti-Infective Agents
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Escherichia coli Proteins
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Ligands
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Triazoles
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Carbon-Nitrogen Ligases
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biotin carboxylase