Developmental and perinatal brain diseases

Homa Adle-Biassette; Jeffery A Golden; Brian Harding

doi:10.1016/B978-0-12-802395-2.00006-7

Developmental and perinatal brain diseases

Handb Clin Neurol. 2017:145:51-78. doi: 10.1016/B978-0-12-802395-2.00006-7.

Authors

Homa Adle-Biassette¹, Jeffery A Golden², Brian Harding³

Affiliations

¹ Department of Pathology, Lariboisière Hospital, APHP and Paris Diderot University, Sorbonne Paris Cité, Paris, France. Electronic address: homa.adle@inserm.fr.
² Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
³ Department of Pathology/Neuropathology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

PMID: 28987191
DOI: 10.1016/B978-0-12-802395-2.00006-7

Abstract

This chapter briefly describes the normal development of the nervous system, the neuropathology and pathophysiology of acquired and secondary disorders affecting the embryo, fetus, and child. They include CNS manifestations of chromosomal change; forebrain patterning defects; disorders of the brain size; cell migration and specification disorders; cerebellum, hindbrain and spinal patterning defects; hydrocephalus; secondary malformations and destructive pathologies; vascular malformations; arachnoid cysts and infectious diseases. The distinction between malformations and disruptions is important for pathogenesis and genetic counseling.

Keywords: brain malformations; child; developmental neuropathology; fetus; genetic; infant; neuropathology; normal brain development.

Publication types

Review

MeSH terms

Brain Diseases / etiology*
Brain* / abnormalities
Brain* / embryology
Brain* / growth & development
Female
Fetal Diseases / physiopathology*
Humans
Infant, Newborn
Male
Nervous System Malformations / complications*
Pregnancy

Grants and funding

R56 NS100007/NS/NINDS NIH HHS/United States