Flavonoid and stilbene derivatives from Macaranga trichocarpa

Abstract

A new farnesylated flavonol (4'-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC₅₀ was 3.5μM.

Keywords: 4′-O-Methylmacagigantin; Cytotoxicity; Euphorbiaceae; Flavonoid; Macaranga trichocarpa; Macatrichocarpin E-H; Stilbene.