Applications of Resting-State Functional MR Imaging to Epilepsy

Alexander Barnett; Samantha Audrain; Mary Pat McAndrews

doi:10.1016/j.nic.2017.06.002

Applications of Resting-State Functional MR Imaging to Epilepsy

Neuroimaging Clin N Am. 2017 Nov;27(4):697-708. doi: 10.1016/j.nic.2017.06.002.

Authors

Alexander Barnett¹, Samantha Audrain¹, Mary Pat McAndrews²

Affiliations

¹ Krembil Research Institute, University Health Network, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; Department of Psychology, University of Toronto, 100 St George Street, Toronto, ON M5S 3G3, Canada.
² Krembil Research Institute, University Health Network, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; Department of Psychology, University of Toronto, 100 St George Street, Toronto, ON M5S 3G3, Canada. Electronic address: Mary.McAndrews@uhn.ca.

PMID: 28985938
DOI: 10.1016/j.nic.2017.06.002

Abstract

We discuss the value of resting-state functional MR imaging (rsfMR imaging) as an emerging technique to address questions about memory and language that are central in surgery for temporal-lobe epilepsy, namely the identification and characterization of eloquent cortex to avoid surgical morbidity. The emergence of a robust set of data using rsfMR imaging has opened new avenues for exploring more direct relationships between neural networks and current cognitive function and prediction of postoperative change. These techniques are also being explored for their potential to characterize epilepsy subtypes, identify epileptic foci, and monitor treatment effects.

Keywords: Functional connectivity; Language; Medial temporal lobe; Memory; fMR imaging.

Publication types

Review

MeSH terms

Brain / diagnostic imaging*
Brain / physiopathology*
Brain Mapping / methods*
Epilepsy / diagnostic imaging*
Epilepsy / physiopathology*
Humans
Magnetic Resonance Imaging / methods*
Neural Pathways / diagnostic imaging
Neural Pathways / physiopathology
Rest