Guardians of the ERAD Galaxy

Zhihao Sun; Jeffrey L Brodsky

doi:10.1016/j.cell.2017.09.023

Guardians of the ERAD Galaxy

Cell. 2017 Oct 5;171(2):267-268. doi: 10.1016/j.cell.2017.09.023.

Authors

Zhihao Sun¹, Jeffrey L Brodsky²

Affiliations

¹ Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
² Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: jbrodsky@pitt.edu.

PMID: 28985557
DOI: 10.1016/j.cell.2017.09.023

Abstract

The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.

Publication types

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MeSH terms

Animals
Endoplasmic Reticulum
Endoplasmic Reticulum-Associated Degradation*
Protein Folding*
Proteins
Secretory Pathway

Substances

Proteins

Abstract

Publication types

MeSH terms

Substances

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