Regulation of signaling pathways by tanshinones in different cancers

Cell Mol Biol (Noisy-le-grand). 2017 Sep 30;63(9):53-58. doi: 10.14715/cmb/2017.63.9.10.

Abstract

Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics. However, the insights gained from work in this natural product research have far-reaching impact because of rapidly increasing repertoire of medicinally and biologically efficient phytochemicals. How Tanshinones mediate targeting of JAK-STAT, ER stress associated signaling cascade,PI3K/AKT/mTOR pathway,autophagy, TRAIL pathway and microRNAs are being discovered and will prove to be helpful in getting a step closer to personalized medicine.

Keywords: Apoptosis.; Cancer; Signaling; TRAIL; Tanshinones.

Publication types

  • Review

MeSH terms

  • Abietanes / pharmacology
  • Abietanes / therapeutic use*
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Apoptosis / drug effects
  • Autophagy / drug effects
  • Drug Evaluation, Preclinical
  • Humans
  • MAP Kinase Signaling System / drug effects
  • Matrix Metalloproteinases / metabolism
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction / drug effects*
  • TNF-Related Apoptosis-Inducing Ligand / metabolism
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Abietanes
  • Antineoplastic Agents, Phytogenic
  • TNF-Related Apoptosis-Inducing Ligand
  • tanshinone
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • Matrix Metalloproteinases