Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Brigitta Matta-Domjan; Alice King; Stella Totti; Csaba Matta; George Dover; Patricia Martinez; Anvar Zakhidov; Roberto La Ragione; Hugo Macedo; Izabela Jurewicz; Alan Dalton; Eirini G Velliou

doi:10.1002/jbm.b.34012

Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1637-1644. doi: 10.1002/jbm.b.34012. Epub 2017 Oct 4.

Authors

Brigitta Matta-Domjan¹, Alice King², Stella Totti¹, Csaba Matta^{3

4}, George Dover⁵, Patricia Martinez⁶, Anvar Zakhidov^{6

7

8}, Roberto La Ragione⁹, Hugo Macedo¹⁰, Izabela Jurewicz⁵, Alan Dalton², Eirini G Velliou¹

Affiliations

¹ Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
² Department of Physics and Astronomy, School of Mathematical and Physical Sciences, University of Sussex, Brighton, BN1 9QH, UK.
³ Department of Veterinary Preclinical Sciences, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK.
⁴ Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
⁵ Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
⁶ NanoTech Institute, University of Texas at Dallas, Richardson, Texas, 75083-068875080.
⁷ National University of Science and Technology, MISIS, Moscow, 119049, Russia.
⁸ Laboratory of Hybrid Nanophotonics and Optoelectronics, Department of Physics and Technology, ITMO University, St. Petersburg, 197101, Russia.
⁹ Department of Pathology and Infectious Diseases, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK.
¹⁰ Smart Separations Ltd., London, UK.

PMID: 28976640
DOI: 10.1002/jbm.b.34012

Abstract

Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1637-1644, 2018.

Keywords: biocompatible pristine carbon nanotube substrate; extracellular matrix; pancreatic adenocarcinoma; pancreatic cancer tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry*
Cell Line, Tumor
Humans
Nanotubes, Carbon / chemistry*
Pancreatic Neoplasms / metabolism*
Pancreatic Neoplasms / pathology
Tissue Engineering*
Tissue Scaffolds / chemistry*

Substances

Biocompatible Materials
Nanotubes, Carbon