Pd-catalyzed desulfitative arylation for the synthesis of 2,5-diarylated oxazole-4-carboxylates using dioxygen as the terminal oxidant

Xiaodong Tang; Kai Yang; Liying Zeng; Qiang Liu; Huoji Chen

doi:10.1039/c7ob01912b

Pd-catalyzed desulfitative arylation for the synthesis of 2,5-diarylated oxazole-4-carboxylates using dioxygen as the terminal oxidant

Org Biomol Chem. 2017 Oct 18;15(40):8504-8507. doi: 10.1039/c7ob01912b.

Authors

Xiaodong Tang¹, Kai Yang, Liying Zeng, Qiang Liu, Huoji Chen

Affiliation

¹ Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, P. R. China.

PMID: 28975186
DOI: 10.1039/c7ob01912b

Abstract

A desulfitative arylation of 2-aryloxazole-4-carboxylate with sodium arylsulfinates under an oxygen (O₂) atmosphere to afford 2,5-diarylated oxazole-4-carboxylates is described. This transformation provides a novel approach for the utilization of sodium arylsulfinates as the aryl source and O₂ as the sole oxidant.