Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

G Kerdivel; V Chesnais; E Becht; A Toma; N Cagnard; F Dumont; A Rousseau; P Fenaux; S Chevret; N Chapuis; V Boeva; W H Fridman; M Fontenay; O Kosmider

doi:10.1038/leu.2017.305

Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

Leukemia. 2018 Feb;32(2):558-562. doi: 10.1038/leu.2017.305. Epub 2017 Oct 3.

Authors

G Kerdivel^{1

2

3

4

5}, V Chesnais^{1

2

3

4

6}, E Becht^{4

7

8}, A Toma⁹, N Cagnard¹⁰, F Dumont^{1

2

3

4

11}, A Rousseau¹², P Fenaux¹³, S Chevret¹⁴, N Chapuis^{1

2

3

4

6

12}, V Boeva^{1

2

3

4

5}, W H Fridman^{4

7}, M Fontenay^{1

2

3

4

6

12}, O Kosmider^{1

2

3

4

6

12}

Affiliations

¹ Institut Cochin, Department Development, Reproduction, Cancer, Paris, France.
² Institut National de la Santé et de la recherche médicale INSERM U1016, Paris, France.
³ Centre National de la recherche scientifique CNRS UMR8104, Paris, France.
⁴ Université Paris Descartes, Paris, France.
⁵ Team Computational (Epi-)Genetics of Cancer, Paris, France.
⁶ Team Normal and pathological hematopoiesis labeled Ligue nationale contre le cancer, Paris, France.
⁷ INSERM UMR_S1138, Cancer, Immune controls and Escape, Cordeliers Research Center, Paris, France.
⁸ Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
⁹ Assistance Publique-Hôpitaux de Paris, Service d'hématologie clinique et Thérapie Cellulaire, Hôpital Henri-Mondor, Créteil, France.
¹⁰ Plateforme Paris Descartes de Bioinformatique, Université Paris Descartes, Paris, France.
¹¹ Plateforme de Génomique, Institut Cochin, Paris, France.
¹² Assistance Publique-Hôpitaux de Paris, Service d'hématologie biologique, Hôpital Cochin, Paris, France.
¹³ Assistance Publique-Hôpitaux de Paris, Service d'hématologie senior, Hôpital Saint-Louis, Paris, France.
¹⁴ Assistance Publique-Hôpitaux de Paris, Laboratoire de Biostatistiques et Epidémiologie clinique INSERM UMR-S 717, Hôpital Saint-Louis, Paris, France.

PMID: 28972593
DOI: 10.1038/leu.2017.305

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Bone Marrow / drug effects*
Chromosome Deletion
Chromosomes, Human, Pair 5 / drug effects*
Chromosomes, Human, Pair 5 / genetics*
Female
Humans
Lenalidomide / therapeutic use*
Male
Middle Aged
Myelodysplastic Syndromes / drug therapy*
Myelodysplastic Syndromes / genetics*
Treatment Outcome

Substances

Lenalidomide