Abstract
Numerous studies have indicated that marine natural products are one of the most important sources of the lead compounds in drug discovery for their unique structures, various bioactivities and less side effects. In this review, the marine natural products with cardiovascular pharmacological effects reported after 2000 will be presented. Their structural types, relevant biological activities, origin of isolation and information of strain species will be discussed in detail. Finally, by describing our studies as an example, we also discuss the chances and challenges for translating marine-derived compounds into preclinical or clinical trials.
Keywords:
Marine; cardiovascular; discovery; marine polysaccharide; natural products; pharmacology.
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MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology
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Alkaloids / therapeutic use
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Animals
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Aquatic Organisms / chemistry
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Biological Products / chemistry
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Biological Products / pharmacology
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Biological Products / therapeutic use*
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Cardiovascular Agents / chemistry
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Cardiovascular Agents / pharmacology
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Cardiovascular Agents / therapeutic use*
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Cardiovascular Diseases / drug therapy*
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Drug Discovery / methods*
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Humans
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Ketones / chemistry
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Ketones / pharmacology
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Ketones / therapeutic use
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Peptides / chemistry
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Peptides / pharmacology
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Peptides / therapeutic use
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Phenols / chemistry
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Phenols / pharmacology
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Phenols / therapeutic use
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Steroids / chemistry
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Steroids / pharmacology
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Steroids / therapeutic use
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Terpenes / chemistry
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Terpenes / pharmacology
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Terpenes / therapeutic use
Substances
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Alkaloids
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Biological Products
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Cardiovascular Agents
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Ketones
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Peptides
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Phenols
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Steroids
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Terpenes