Dependent generalized Dirichlet process priors for the analysis of acute lymphoblastic leukemia

Biostatistics. 2018 Jul 1;19(3):342-358. doi: 10.1093/biostatistics/kxx042.

Abstract

We propose a novel Bayesian nonparametric process prior for modeling a collection of random discrete distributions. This process is defined by including a suitable Beta regression framework within a generalized Dirichlet process to induce dependence among the discrete random distributions. This strategy allows for covariate dependent clustering of the observations. Some advantages of the proposed approach include wide applicability, ease of interpretation, and availability of efficient MCMC algorithms. The motivation for this work is the study of the impact of asparginage metabolism on lipid levels in a group of pediatric patients treated for acute lymphoblastic leukemia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Asparaginase / administration & dosage
  • Asparaginase / pharmacology*
  • Bayes Theorem
  • Biostatistics*
  • Child
  • Data Interpretation, Statistical*
  • Humans
  • Models, Statistical*
  • Outcome Assessment, Health Care / methods*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Statistics, Nonparametric

Substances

  • Antineoplastic Agents
  • Asparaginase