All Paths Lead to TRIM25

Trends Cancer. 2017 Oct;3(10):673-675. doi: 10.1016/j.trecan.2017.08.005.

Abstract

Identifying key factors that regulate the transition from primary to metastatic cancer is a fundamental challenge. Walsh et al. took a systems biology approach integrating computational, in vitro, and in vivo experiments to identify TRIM25 (tripartite motif containing 25) as a key factor that regulates metastatic gene signatures both at the transcriptional and post-transcriptional level in breast cancer. Targeting TRIM25 therapeutically is attractive because it governs a broad set of coordinated transcriptional modules that dictate metastatic progression.

Keywords: TRIM25; breast cancer; metastasis; network inference; transcription.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biomarkers, Tumor*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Female
  • Humans
  • Neoplasm Metastasis
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Tripartite Motif Proteins / genetics*
  • Tripartite Motif Proteins / metabolism*
  • Ubiquitin-Protein Ligases / genetics*
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Biomarkers, Tumor
  • Transcription Factors
  • Tripartite Motif Proteins
  • TRIM25 protein, human
  • Ubiquitin-Protein Ligases