The nonlinear ellipse rotation usually occurs when an elliptically polarized beam propagates through an isotropic nonlinear medium owing to the existence of χ1221(3). Here we report the radial-variant nonlinear ellipse rotation of a vector beam with structured elliptical polarization through isotropic Kerr nonlinearities. Due to the interaction of elliptically polarized vector beams (EPVBs) with isotropic nonlinear media, the distributions of both the orientation angle and the ellipticity angle of beams at the far-field observational plane exhibit multiple concentric ring structures with the circularly symmetry. Numerical simulations show that the self-diffraction intensity pattern, the distribution of the state of polarization, and the spin angular momentum (SAM) distribution of an EPVB could be manipulated by tuning both the isotropic optical nonlinearity and the chirality parameter of the vector beam, which may find direct applications in polarization-control optical switching, SAM manipulation, and optical polarization encoding or detection.