Verapamil-induced breakdown of the blood-brain barrier presenting as a transient right middle cerebral artery syndrome

Interv Neuroradiol. 2017 Dec;23(6):601-604. doi: 10.1177/1591019917729822. Epub 2017 Sep 28.

Abstract

A middle-aged patient presented for elective embolization of an incidentally found right internal carotid aneurysm. An angiogram was performed, during which the left internal carotid artery was visualized to evaluate a second, small aneurysm. During the embolization of the right internal carotid artery aneurysm, a catheter-induced vasospasm was identified that prompted treatment with intra-arterial verapamil. The procedure was uncomplicated; a postoperative rotational flat-panel computed tomography scan was performed on the angiography table that demonstrated right hemisphere contrast staining. The patient developed a right middle cerebral artery (MCA) syndrome after extubation with repeat cerebral angiography negative for occlusion and magnetic resonance imaging negative for stroke. The patient was observed for 48 hours, during which time the patient had slowly improved. At a six-week follow up visit, the patient had fully recovered. We present an interesting case of a verapamil-induced breakdown of the blood-brain barrier and self-limited right MCA syndrome.

Keywords: Cerebrovascular; Pipeline Embolization Device; verapamil.

Publication types

  • Case Reports

MeSH terms

  • Blood-Brain Barrier / drug effects*
  • Carotid Artery, Internal / diagnostic imaging*
  • Cerebral Angiography
  • Computed Tomography Angiography*
  • Contrast Media
  • Electroencephalography
  • Embolization, Therapeutic / methods*
  • Humans
  • Infarction, Middle Cerebral Artery / diagnostic imaging*
  • Intracranial Aneurysm / diagnostic imaging*
  • Intracranial Aneurysm / therapy*
  • Middle Aged
  • Middle Cerebral Artery / diagnostic imaging*
  • Syndrome
  • Vasodilator Agents / adverse effects*
  • Verapamil / adverse effects*

Substances

  • Contrast Media
  • Vasodilator Agents
  • Verapamil