Isolation and characterization of metabolites produced by endophytes are significant ways to search for novel natural active substances, proving that the endophytes are the unique resources of newer and more effective compounds. Many new compounds with antimicrobial activity from different endophytes have been isolated so far. These new compounds provide alternatives to fight against multi-drug resistance of microorganisms. This review outlined the major achievements and latest developments of endophytes, including the diversity of endophytes and antimicrobial activity of endophytes, as well as its development in China.
植物内生菌作为一种新型的微生物资源，分离和确定其代谢产物是一条寻找新型天然活性物质的重要途径。目前为止，许多研究者从不同的植物内生菌中分离到大量具有抗菌活性的新化合物，这些新的化合物被认为是解决日益严重的微生物多重耐药性的希望之一。本文从植物内生菌的多样性、抗菌活性物质多样性及国内内生菌研究进展等多个角度概述了当前有关植物内生菌研究的主要成果和最新进展，以期为植物内生菌相关研究提供借鉴。.
Keywords: antimicrobial activity; endophyte; secondary metabolites.