Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

Hyowon Seo; Aofei Liu; Timothy F Jamison

doi:10.1021/jacs.7b05942

Direct β-Selective Hydrocarboxylation of Styrenes with CO₂ Enabled by Continuous Flow Photoredox Catalysis

J Am Chem Soc. 2017 Oct 11;139(40):13969-13972. doi: 10.1021/jacs.7b05942. Epub 2017 Sep 27.

Authors

Hyowon Seo¹, Aofei Liu¹, Timothy F Jamison¹

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

PMID: 28953365
DOI: 10.1021/jacs.7b05942

Abstract

The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO₂ has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as α-substituted and β-substituted styrenes.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't