Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender

Curr Hematol Malig Rep. 2017 Oct;12(5):424-431. doi: 10.1007/s11899-017-0411-0.

Abstract

The myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) display distinct clinical and pathologic features but are characterized by mutations in JAK2, MPL, and CALR leading to activation of the JAK-STAT pathway. This review addresses the pathogenesis and mechanisms of these mutant alleles and the unique interactions of both of age and gender.

Keywords: Aging; JAK2; Myeloproliferative neoplasms; Pathogenesis; Sex differences.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Aging* / genetics
  • Aging* / metabolism
  • Aging* / pathology
  • Alleles
  • Female
  • Hematologic Neoplasms / genetics
  • Hematologic Neoplasms / metabolism
  • Hematologic Neoplasms / pathology
  • Humans
  • Janus Kinase 2* / genetics
  • Janus Kinase 2* / metabolism
  • Male
  • Mutation*
  • Myeloproliferative Disorders* / genetics
  • Myeloproliferative Disorders* / metabolism
  • Myeloproliferative Disorders* / pathology
  • Receptors, Thrombopoietin* / genetics
  • Receptors, Thrombopoietin* / metabolism
  • Sex Characteristics*
  • Sex Factors

Substances

  • Receptors, Thrombopoietin
  • MPL protein, human
  • JAK2 protein, human
  • Janus Kinase 2