Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase

Bull Exp Biol Med. 2017 Sep;163(5):695-698. doi: 10.1007/s10517-017-3881-0. Epub 2017 Sep 25.

Abstract

Validation of the method for studies of glucokinase activators by the spectrophotometric method in an in vitro test system is carried out. The advantage of NAD coenzyme vs. thio-NAD is proven. Manifest activation of glucokinase by MBX-2982 compound (GPR119 agonist) in a wide range of concentrations is demonstrated experimentally.

Keywords: glucokinase; glucokinase activators; hexokinase; type 2 diabetes mellitus.

MeSH terms

  • Enzyme Activation / drug effects
  • Glucokinase / metabolism*
  • Humans
  • Molecular Structure
  • Receptors, G-Protein-Coupled / metabolism
  • Tetrazoles / chemistry
  • Tetrazoles / pharmacology*
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*

Substances

  • GPR119 protein, human
  • MBX-2982
  • Receptors, G-Protein-Coupled
  • Tetrazoles
  • Thiazoles
  • Glucokinase