Role of the intestinal microbiota in the immunomodulation of influenza virus infection

Chi-Jene Chen; Guan-Hong Wu; Rei-Lin Kuo; Shin-Ru Shih

doi:10.1016/j.micinf.2017.09.002

Role of the intestinal microbiota in the immunomodulation of influenza virus infection

Microbes Infect. 2017 Dec;19(12):570-579. doi: 10.1016/j.micinf.2017.09.002. Epub 2017 Sep 19.

Authors

Chi-Jene Chen¹, Guan-Hong Wu², Rei-Lin Kuo³, Shin-Ru Shih⁴

Affiliations

¹ Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan; Research Center for Emerging Viruses, China Medical University Hospital, Taichung, Taiwan.
² Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
³ Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address: rlkuo@mail.cgu.edu.tw.
⁴ Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Clinical Virology Laboratory, Department of Laboratory Science, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address: srshih@mail.cgu.edu.tw.

PMID: 28939355
DOI: 10.1016/j.micinf.2017.09.002

Abstract

Prevention and treatment measures against influenza virus infection remain limited, and alternative host protection strategies are badly needed. In this review, we discuss the regulatory role of intestinal microbiota in influenza infections, and present the latest evidence for strategies seeking to harness gut microbiota for the management of influenza infections.

Keywords: Gut-lung axis; Immunomodulation; Influenza virus; Intestinal microbiota; Vaccination.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Gastrointestinal Microbiome / immunology*
Humans
Immunomodulation / immunology*
Influenza, Human / prevention & control*
Influenza, Human / virology
Intestines / microbiology*