"Gamete On" for m6A: YTHDF2 Exerts Essential Functions in Female Fertility

Boxuan Simen Zhao; Chuan He

doi:10.1016/j.molcel.2017.09.004

"Gamete On" for m⁶A: YTHDF2 Exerts Essential Functions in Female Fertility

Mol Cell. 2017 Sep 21;67(6):903-905. doi: 10.1016/j.molcel.2017.09.004.

Authors

Boxuan Simen Zhao¹, Chuan He²

Affiliations

¹ Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, 929 East 57th Street, The University of Chicago, Chicago, Illinois 60637, USA.
² Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, 929 East 57th Street, The University of Chicago, Chicago, Illinois 60637, USA. Electronic address: chuanhe@uchicago.edu.

PMID: 28938096
DOI: 10.1016/j.molcel.2017.09.004

Abstract

In this issue of Molecular Cell, Ivanova et al. (2017) report key functions of the m⁶A reader YTHDF2 in the regulation of mammalian development during oocyte maturation and early zygotic development.

MeSH terms

Animals
Female
Fertility
Germ Cells*
Humans
Oocytes
Oogenesis
Zygote*