Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice

Angelina Dr Felix; Nobuyuki Takahashi; Mami Takahashi; Rie Katsumata-Tsuboi; Ryo Satoh; Teoh Soon Hui; Katsuhiro Miyajima; Dai Nakae; Hirofumi Inoue; Mariko Uehara

doi:10.1080/09168451.2017.1372178

Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice

Biosci Biotechnol Biochem. 2017 Nov;81(11):2209-2211. doi: 10.1080/09168451.2017.1372178. Epub 2017 Sep 22.

Authors

Affiliations

¹ a Laboratory of Physiology and Metabolism, Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience , Tokyo University of Agriculture , Tokyo , Japan.
² b Institute of Human Nutrition and Food , University of the Philippines Los Banos College of Human Ecology , Laguna , Philippines.
³ c Laboratory of Food Safety Assessment Science, Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience , Tokyo University of Agriculture , Tokyo , Japan.

PMID: 28934910
DOI: 10.1080/09168451.2017.1372178

Abstract

Rice powder extract (RPE) from black and brown rice (Oryza sativa L. indica) improves hepatic lipid accumulation in obese and diabetic model mice via peroxisomal fatty acid oxidation. RPE showed PPARα agonistic activity which did not differ between black and brown RPE despite a higher anthocyanin content in black RPE.

Keywords: PPAR; fatty acid oxidation; lipid metabolism; liver; rice powder.

MeSH terms

Animals
Diabetes Mellitus / drug therapy
Diabetes Mellitus / metabolism*
Disease Models, Animal
Fatty Acids / metabolism
Lipid Metabolism / drug effects*
Liver / drug effects*
Liver / metabolism
Mice
Obesity / drug therapy
Obesity / metabolism*
Oryza / chemistry*
PPAR alpha / metabolism*
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Powders

Substances

Fatty Acids
PPAR alpha
Plant Extracts
Powders