Ixodicides resistance of ticks is one of the most important problems for the livestock industry in tropical and subtropical regions, mainly due to the increase in cases of multiple resistance in all families of the ixodicides used. Molecular markers such as single nucleotide polymorphisms (SNPs) has been proposed to identify the resistance to ixodicides in Rhipicephalus microplus. Many studies have recently been conducted using SNPs and other types of molecular markers to determine if they are associated with resistance to different products in many parts of the world. Knowing these changes at the molecular level, will allow to establish mechanisms and control strategies for the use of ixodicides. In this review, we will discuss and describe the different SNPs and other polymorphisms associated with resistance in R. microplus.