Abstract
The spread of bacterial infectious diseases due to the development of resistance to antibiotic drugs in pathogenic bacteria is an emerging global concern. Therefore, the efficacious management and prevention of bacterial infections are major public health challenges. RecA is a pleiotropic recombinase protein that has been demonstrated to be implicated strongly in the bacterial drug resistance, survival and pathogenicity. In this minireview, RecA's role in the development of antibiotic resistance and its potential as an antimicrobial drug target are discussed.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / genetics
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Bacteria / pathogenicity
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Bacterial Infections / microbiology
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Bacterial Proteins / antagonists & inhibitors*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Drug Resistance, Bacterial / genetics
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Humans
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Microbial Viability / drug effects
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Microbial Viability / genetics
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Mutation
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Rec A Recombinases / antagonists & inhibitors*
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Rec A Recombinases / genetics
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Rec A Recombinases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Rec A Recombinases