Single-step synthesis of carbon encapsulated magnetic nanoparticles in arc plasma and potential biomedical applications

Xiuqi Fang; Xiaoqian Cheng; Yuerou Zhang; Lijie Grace Zhang; Michael Keidar

doi:10.1016/j.jcis.2017.09.015

Single-step synthesis of carbon encapsulated magnetic nanoparticles in arc plasma and potential biomedical applications

J Colloid Interface Sci. 2018 Jan 1:509:414-421. doi: 10.1016/j.jcis.2017.09.015. Epub 2017 Sep 7.

Authors

Xiuqi Fang¹, Xiaoqian Cheng², Yuerou Zhang³, Lijie Grace Zhang², Michael Keidar⁴

Affiliations

¹ Department of Mechanical & Aerospace Engineering, The George Washington University, Washington DC 20052, USA. Electronic address: xiuqifang@gwmail.gwu.edu.
² Department of Mechanical & Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
³ Physics Science & Engineering Department, Tongji University, Shanghai 200092, China.
⁴ Department of Mechanical & Aerospace Engineering, The George Washington University, Washington DC 20052, USA. Electronic address: keidar@gwu.edu.

PMID: 28923738
DOI: 10.1016/j.jcis.2017.09.015

Abstract

A novel highly controllable process of Carbon Encapsulated Magnetic Nanoparticles (CEMNs) synthesis in arc discharge plasma has been developed. In this work, both the size distribution and the purity of the CEMNs have been made more controllable by adding an external magnetic field. It is shown that with the increase of the external magnetic field, the CEMNs get a better separation from the carbon impurities and the size distribution become narrower. This conclusion is valid for Fe, Ni and Fe+Ni CEMNs synthesis. In order to assess biomedical potential of these CEMNs, the cytotoxicity has also been measured for the human breast adenocarcinoma cell line MDA-MB-231. It was concluded that the CEMNs with the concentration in cell of about 0.0001-0.01ug/ml are not toxic.

Keywords: Arc discharge; Biomedical; CEMNs; Synthesis.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Carbon / chemistry*
Cell Line, Tumor
Cell Survival
Humans
Iron / chemistry
Magnetite Nanoparticles / chemistry*
Nanocomposites / chemistry*
Nickel / chemistry
Particle Size
Surface Properties

Substances

Antineoplastic Agents
Magnetite Nanoparticles
Carbon
Nickel
Iron